Abstract
Abstract
Genetic polymorphism can result in abnormal pharmacodynamics that subsequently leads to the individual variance in sedative effects and adverse reactions. The aim of this study was to elucidate the association between midazolam-related genetic polymorphism and sedative effects, including adverse reactions, under conscious sedation during upper gastrointestinal endoscopy. We prospectively enrolled 100 eligible patients undergoing upper gastrointestinal endoscopy. The efficacy of the sedation, adverse reactions, plasma concentration of midazolam and 1-hydroxymidazolam were investigated as well as the genetic polymorphism of MDR1 and CYP3A5. The correlation between genetic polymorphism and sedative effects was assessed. Regarding MDR1 gene, the plasma concentration of midazolam was greater in patients with CGC haplotype (P = 0.012), while it was lower in patients with CAC haplotype (P = 0.005) than in those with other haplotypes. However, genetic polymorphism of neither MDR1 nor CYP3A5 correlated with the plasma concentration of 1-hydroxymidazolam. CGT haplotype of MDR1 was significantly correlated with sedation grade after midazolam administration (P = 0.042). In contrast, genetic polymorphism of CYP3A5 was not correlated with sedation grade. There was no association between genetic polymorphism of MDR1 or CYP3A5 and selected adverse reactions related to midazolam. Genetic polymorphism of MDR1 influences the concentration of midazolam and the sedation grade. However, it is not associated with adverse reactions such as paradoxical response and retrograde amnesia.
Publisher
Springer Science and Business Media LLC
Reference20 articles.
1. Yi, S. Y. & Shin, J. E. Midazolam for patients undergoing upper gastrointestinal endoscopy: A prospective, single-blind and randomized study to determine the appropriate amount and time of initiation of endoscopy. J Gastroen Hepatol 20, 1873–1879,
https://doi.org/10.1111/j.1440-1746.2005.04081.x
(2005).
2. Wu, W., Chen, Q., Zhang, L. C. & Chen, W. H. Dexmedetomidine versus midazolam for sedation in upper gastrointestinal endoscopy. J Int Med Res 42, 516–522,
https://doi.org/10.1177/0300060513515437
(2014).
3. Triantafillidis, J. K., Merikas, E., Nikolakis, D. & Papalois, A. E. Sedation in gastrointestinal endoscopy: current issues. World J Gastroenterol 19, 463–481,
https://doi.org/10.3748/wjg.v19.i4.463
(2013).
4. Lee, S. Y. et al. Identification of factors that influence conscious sedation in gastrointestinal endoscopy. J Korean Med Sci 19, 536–540, doi:D - NLM: PMC2816887 EDAT- 2004/08/17 10:00 MHDA- 2005/08/05 09:00 CRDT- 2004/08/17 10:00 AID - 200408536 [pii] PST - ppublish (2004).
5. Massanari, M., Novitsky, J. & Reinstein, L. J. Paradoxical reactions in children associated with midazolam use during endoscopy. Clin Pediatr 36, 681–684,
https://doi.org/10.1177/000992289703601202
(1997).
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