Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition
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Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-05895-9.pdf
Reference37 articles.
1. Arjona, O., Gómez, A. M., López, J. C. & Plumet, J. Synthesis and conformational and biological aspects of carbasugars. Chem Rev. 107, 1919–2036 (2007).
2. Lahiri, R., Ansari, A. A. & Vankar, Y. D. Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors. Chem Soc Rev. 42, 5102–5118 (2013).
3. Kameda, Y., Asano, N., Yamaguchi, T. & Matsui, K. Validoxylamines as trehalase inhibitors. J Antibiot (Tokyo). 40, 563–565 (1987).
4. Asano, N., Takeuchi, M., Kameda, Y., Matsui, K. & Kono, Y. Trehalase inhibitors, validoxylamine A and related compounds as insecticides. J Antibiot (Tokyo). 43, 722–726 (1990).
5. Shing, T. K. M. et al. Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent. Org Lett. 10, 3145–3148 (2008).
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