Abstract
AbstractKidney transplantation (KT) is associated with a substantial risk of postoperative complications (POC) for which performant predictors are lacking. Data showed that a perioperative gain of weight (ΔWeight) was associated with higher risk of POC, but it remains unexplored in KT. This retrospective study aimed to investigate the association between ΔWeight and POC after KT. ΔWeight was calculated on postoperative day (POD) 2. POC were graded according to the Dindo-Clavien classification. Primary endpoint was overall POC. A total of 242 patients were included and 174 (71.9%) complications were reported. Patients showed a rapid gain of weight after KT. Mean ΔWeight was 7.83 kg (± 3.20) compared to 5.3 kg (± 3.56) in patients with and without complication, respectively (p = 0.0005). ΔWeight showed an accuracy of 0.74 for overall POC. A cut-off of 8.5 kg was determined. ΔWeight ≥ 8.5 kg was identified as an independent predictor of overall POC on multivariable analysis (OR 2.04; 95% CI 1.08–3.84; p = 0.025). ΔWeight ≥ 8.5 kg appeared as an independent predictor of POC after KT. These results stress the need to monitor weight in KT and to further investigate this surrogate with future studies assessing its clinical relevance.
Publisher
Springer Science and Business Media LLC
Reference22 articles.
1. Wolfe, R. A. et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N. Engl. J. Med. 341, 1725–1730. https://doi.org/10.1056/NEJM199912023412303 (1999).
2. Hashimoto, Y. et al. Surgical complications in kidney transplantation: experience from 1200 transplants performed over 20 years at six hospitals in central Japan. Transplant. Proc. 28, 1465–1467 (1996).
3. Eufrasio, P. et al. Surgical complications in 2000 renal transplants. Transplant. Proc. 43, 142–144. https://doi.org/10.1016/j.transproceed.2010.12.009 (2011).
4. Schreiber, P. W. et al. Surgical site infections after kidney transplantation are independently associated with graft loss. Am. J. Transplant. https://doi.org/10.1016/j.ajt.2023.11.013 (2023).
5. Foucher, Y. et al. A clinical scoring system highly predictive of long-term kidney graft survival. Kidney Int. 78, 1288–1294. https://doi.org/10.1038/ki.2010.232 (2010).