Author:
Wernroth Mona-Lisa,Peura Sari,Hedman Anna M.,Hetty Susanne,Vicenzi Silvia,Kennedy Beatrice,Fall Katja,Svennblad Bodil,Andolf Ellika,Pershagen Göran,Theorell-Haglöw Jenny,Nguyen Diem,Sayols-Baixeras Sergi,Dekkers Koen F.,Bertilsson Stefan,Almqvist Catarina,Dicksved Johan,Fall Tove
Abstract
AbstractAlthough development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA sequencing to analyse faecal and saliva samples from 83 children at four time-points during their first 2 years of life and from their mothers. Our findings confirm that gut microbiota in infants have low diversity and highlight that some properties are shared with the oral microbiota, although inter-individual differences are present. A considerable convergence in gut microbiota composition was noted across the first 2 years of life, towards a more diverse adult-like microbiota. Mode of delivery accounted for some of the inter-individual variation in early childhood, but with a pronounced attenuation over time. Our study extends previous research with further characterization of the major shift in gut microbiota composition during the first 2 years of life.
Funder
Vetenskapsrådet
Swedish Initiative for Research on Microdata in the Social And Medical Sciences
the Strategic Research Program in Epidemiology at Karolinska Institutet
Forskningsrådet om Hälsa, Arbetsliv och Välfärd
Hjärt-Lungfonden
Uppsala Antibiotic Center
EXODIAB
Diabetesfonden
European Research Council Starting Grant
Uppsala University
Publisher
Springer Science and Business Media LLC
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