Author:
Lång Maarit,Jakob Stephan M.,Takala Riikka,Lyngbakken Magnus N.,Turpeinen Anu,Omland Torbjørn,Merz Tobias M.,Wiegand Jan,Grönlund Juha,Rahi Melissa,Valtonen Mika,Koivisto Timo,Røsjø Helge,Bendel Stepani
Abstract
AbstractSubarachnoid hemorrhage (SAH) is a serious condition, and a myocardial injury or dysfunction could contribute to the outcome. We assessed the prevalence and prognostic impact of cardiac involvement in a cohort with SAH. This is a prospective observational multicenter study. We included 192 patients treated for non-traumatic subarachnoid hemorrhage. We performed ECG recordings, echocardiographic examinations, and blood sampling within 24 h of admission and on days 3 and 7 and at 90 days. The primary endpoint was the evidence of cardiac involvement at 90 days, and the secondary endpoint was to examine the prevalence of a myocardial injury or dysfunction. The median age was 54.5 (interquartile range [IQR] 48.0–64.0) years, 44.3% were male and the median World Federation of Neurological Surgeons (WFNS) score was 2 (IQR 1–4). At day 90, 22/125 patients (17.6%) had left ventricular ejection fractions ≤ 50%, and 2/121 patients (1.7%) had evidence of a diastolic dysfunction as defined by mitral peak E-wave velocity by peak eʹ velocity (E/eʹ) > 14. There was no prognostic impact from echocardiographic evidence of cardiac complications on neurological outcomes. The overall prevalence of cardiac dysfunction was modest. We found no demographic or SAH-related factors associated with 90 days cardiac dysfunction.
Funder
Åkershus University Hospital research funding
State reseach funding
Finnish intensice care society grant
Publisher
Springer Science and Business Media LLC
Reference21 articles.
1. Chen, S. et al. The harmful effects of subarachnoid hemorrhage on extracerebral organs. Biomed. Res. Int. 2014, 858496 (2014).
2. Lee, V. H., Oh, J. K., Mulvagh, S. L. & Wijdicks, E. F. Mechanisms in neurogenic stress cardiomyopathy after aneurysmal subarachnoid hemorrhage. Neurocrit. Care. 5, 243–249 (2006).
3. Mayer, S. A. et al. Myocardial injury and left ventricular performance after subarachnoid hemorrhage. Stroke 30, 780–786 (1999).
4. Tung, P. et al. Predictors of neurocardiogenic injury after subarachnoid hemorrhage. Stroke 35, 548–551 (2004).
5. Sakr, Y. L., Ghosn, I. & Vincent, J. L. Cardiac manifestations after subarachnoid hemorrhage: A systematic review of the literature. Prog. Cardiovasc. Dis. 45, 67–80 (2002).
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