Author:
Mehmood Tahir,Iqbal Mudassir,Rafique Bushra
Abstract
AbstractImidazole has anti-inflammatory, antituberculotic, antimicrobial, antimycotic, antiviral, and antitumor properties in the human body, to name a few. Metronidazole [1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole] is a widely used antiprotozoan and antibacterial medication. Using fourier transform infrared spectroscopy, the current study models the antibacterial activity of already synthesised Metronidazole (MTZ) complexes ($$MTZ-Benz$$
M
T
Z
-
B
e
n
z
, $$MTZ-Benz-Cu$$
M
T
Z
-
B
e
n
z
-
C
u
, $$MTZ-Benz-Cu-Cl_2CHCOOH$$
M
T
Z
-
B
e
n
z
-
C
u
-
C
l
2
C
H
C
O
O
H
, $$MTZ$$
MTZ
, $$MTZ-Cu$$
M
T
Z
-
C
u
, $$MTZ-Cu-Cl_2CHCOOH$$
M
T
Z
-
C
u
-
C
l
2
C
H
C
O
O
H
, $$MTZ-Benz-Ag$$
M
T
Z
-
B
e
n
z
-
A
g
, $$MTZ-Benz-Ag-Cl_2CHCOOH$$
M
T
Z
-
B
e
n
z
-
A
g
-
C
l
2
C
H
C
O
O
H
, $$MTZ-Ag$$
M
T
Z
-
A
g
and $$MTZ-Ag-Cl_2CHCOOH$$
M
T
Z
-
A
g
-
C
l
2
C
H
C
O
O
H
) against E. coli, B. bronceptica, S. epidermidis, B. pumilus and S. aureus. To characterise the Metronidazole complexes for antibacterial activity against 05 microbes, the least angular regression and least absolute shrinkage selection operators were used. Asymmetric Least Squares was used to correct the spectrum baseline. Least angular regression outperforms cross-validated root mean square error in the fitted models. Using Least angular regression, influential wavelengths that explain the variation in antibacterial activity of Metronidazole complexes were identified and mapped against functional groups.
Publisher
Springer Science and Business Media LLC
Reference34 articles.
1. Timmerman, H., Mannhold, R. & Krogsgaard-Larsen, P. Chemometric Methods in Molecular Design Vol. 2 (Wiley, 2008).
2. Bempong, D. K., Manning, R. G., Mirza, T. & Bhattacharyya, L. A stability-indicating HPLC assay for metronidazole benzoate. J. Pharm. Biomed. Anal. 38, 776–780 (2005).
3. Dubcy, S., Jain, V. & Preethi, G. Evaluation of lipophilicity, antimicrobial activity and mutagenicity of some novel ester prodrugs of metronidazole. Indian J. Chem. Sect. B 48, 1571–1576 (2009).
4. Pandeya, K. B. et al. A critical review on traditional herbal drugs: An emerging alternative drug for diabetes. Int. J. Organ. Chem. 3, 1–22 (2013).
5. Seguel, G. V., Rivas, B. L., Moreno, Y. & Peña, O. Poly (dl-aspartic acid) and copper (ii) acetate monohydrate interactions. Transit. Metal Chem. 32, 1106–1109 (2007).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献