Author:
Comunale Giulia,Peruzzo Paolo,Castaldi Biagio,Razzolini Renato,Di Salvo Giovanni,Padalino Massimo A.,Susin Francesca M.
Abstract
AbstractThe role played by the right ventricular (RV) dysfunction has long been underestimated in clinical practice. Recent findings are progressively confirming that when the RV efficiency deteriorates both the right and the left circulation is (significantly) affected, but studies dedicated to a detailed description of RV hemodynamic role still lack. In response to such a gap in knowledge, this work proposes a numerical model that for the first time evaluates the effect of isolated RV dysfunction on the whole circulation. Lumped parameter modelling was applied to represent the physio-pathological hemodynamics. Different grades of impairment were simulated for three dysfunctions i.e., systolic, diastolic, and combined systolic and diastolic. Hemodynamic alterations (i.e., of blood pressure, flow, global hemodynamic parameters), arising from the dysfunctions, are calculated and analysed. Results well accord with clinical observations, showing that RV dysfunction significantly affects both the pulmonary and systemic hemodynamics. Successful verification against in vivo data proved the clinical potentiality of the model i.e., the capability of identifying the degree of RV impairment for given hemodynamic conditions. This study aims at contributing to the improvement of RV dysfunction recognition and treatment, and to the development of tools for the clinical management of pathologies involving the right heart.
Publisher
Springer Science and Business Media LLC
Reference60 articles.
1. Sun, J. C. & Joffe, H. The Most Common Inpatient Problems in Internal Medicine E-Book: Ward Survival (Elsevier Health Sciences, Amsterdam, 2007).
2. Bonnema, D. D., Baicu, C. F. & Zile, M. R. Pathophysiology of Diastolic Heart Failure: Relaxation and Stiff ness. in Diastology Clinical Approach to Diastolic Heart Failure 11–25 (Elsevier Inc., 2008). https://doi.org/10.1016/B978-1-4160-3754-5.50008-1
3. Treece, J. et al. A review of prognostic tools in heart failure. Am. J. Hosp. Palliat. Med. 35, 514–522 (2018).
4. Haddad, F., Doyle, R., Murphy, D. J. & Hunt, S. A. Right ventricular function in cardiovascular disease, part II: Pathophysiology, clinical importance, and management of right ventricular failure. Circulation 117, 1717–1731 (2008).
5. Kagan, A. Dynamic responses of the right ventricle following extensive damage by cauterization. Circulation 5, 816–823 (1952).
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