Author:
Sidorenko Irina,Turova Varvara,Botkin Nikolai,Kovtanyuk Andrey,Eckardt Laura,Alves-Pinto Ana,Felderhoff-Müser Ursula,Rieger-Fackeldey Esther,Lampe Renée
Abstract
AbstractThe development of intraventricular haemorrhages (IVH) in preterm newborns is triggered by a disruption of the vessels responsible for cerebral microcirculation. Analysis of the stresses exerted on vessel walls enables the identification of the critical values of cerebral blood flow (CBF) associated with the development of IVH in preterm infants. The purpose of the present study is the estimation of these critical CBF values using the biomechanical stresses obtained by the finite element modelling of immature brain capillaries. The properties of the endothelial cells and basement membranes employed were selected on the basis of published nanoindentation measurements using atomic force microscopes. The forces acting on individual capillaries were derived with a mathematical model that accounts for the peculiarities of microvascularity in the immature brain. Calculations were based on clinical measurements obtained from 254 preterm infants with the gestational age ranging from 23 to 30 weeks, with and without diagnosis of IVH. No distinction between the affected and control groups with the gestational age of 23 to 26 weeks was possible. For infants with the gestational age of 27 to 30 weeks, the CBF value of 17.03 ml/100 g/min was determined as the critical upper value, above which the likelihood of IVH increases.
Funder
Klaus Tschira Stiftung
Buhl Foundation
Buhl-Strohmaier Foundation
Publisher
Springer Science and Business Media LLC
Reference38 articles.
1. de Vries, L. S., van Haastert, I. L. C., Rademaker, K. J., Koopman, C. & Groenendaal, F. Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. J Pediatr. 144, 815–820 (2004).
2. Hambleton, G. & Wigglesworth, J. S. Origin of intraventricular haemorrhage in the preterm infant. Arch. Dis. Child. 51, 651–659 (1976).
3. Sajadian, N., Fakhraei, H. & Jahadi, R. Incidence of intraventricular hemorrhage and post hemorrhagic hydrocephalus in preterm infants. Acta Med. Iran. 48, 260–262 (2010).
4. Kinoshita, Y., Okudera, T., Tsuru, E. & Yokota, A. Volumetric analysis of the germinal matrix and lateral ventricles performed using MR images of postmortem fetuses. AJNR Am. J. Neuroradiol. 22, 382–388 (2001).
5. Trommer, B. L., Groothuis, D. R. & Pasternak, J. F. Quantitative analysis of cerebral vessels in the newborn puppy: the structure of germinal matrix vessels may predispose to hemorrhage. Pediatr. Res. 22, 23–28 (1987).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献