Author:
Rajagopal Veera M.,Ganna Andrea,Coleman Jonathan R. I.,Allegrini Andrea,Voloudakis Georgios,Grove Jakob,Als Thomas D.,Horsdal Henriette T.,Petersen Liselotte,Appadurai Vivek,Schork Andrew,Buil Alfonso,Bulik Cynthia M.,Bybjerg-Grauholm Jonas,Bækvad-Hansen Marie,Hougaard David M.,Mors Ole,Nordentoft Merete,Werge Thomas,Belliveau Rich,Carey Caitlin E.,Cerrato Felecia,Chambert Kimberly,Churchhouse Claire,Daly Mark J.,Dumont Ashley,Goldstein Jacqueline,Hansen Christine S.,Howrigan Daniel P.,Huang Hailiang,Maller Julian,Martin Alicia R.,Martin Joanna,Mattheisen Manuel,Moran Jennifer,Neale Benjamin M.,Pallesen Jonatan,Palmer Duncan S.,Pedersen Carsten Bcker,Pedersen Marianne Giørtz,Poterba Timothy,Ripke Stephan,Satterstrom F. Kyle,Thompson Wesley K.,Turley Patrick,Walters Raymond K.,Mortensen Preben Bo,Breen Gerome,Roussos Panos,Plomin Robert,Agerbo Esben,Børglum Anders D.,Demontis Ditte,
Abstract
AbstractCognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.
Funder
Lundbeckfonden
South London and Maudsley NHS Foundation Trust
Maudsley Charity
Guy's and St Thomas' Charity
HORIZON EUROPE Marie Sklodowska-Curie Actions
Leon Levy Foundation
Klarman Family Foundation
NIHR Collaboration for Leadership in Applied Health Research and Care South London
National Institutes of Health
U.S. Department of Veterans Affairs
Novo Nordisk Fonden
National Institute of Mental Health
Publisher
Springer Science and Business Media LLC