Author:
Huang Xiaoyu,Tang Jianming,Chen Mao,Xiao Ya,Zhu Fangyi,Chen Liying,Tian Xiaoyu,Hong Li
Abstract
AbstractUrogenital congenital anomalies (UCAs) is defined as “any live-birth with a urinary or genital condition” and affects millions of men and women worldwide. However, sex differences and related environmental risk factors in UCAs burden on a global scale have not been assessed. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated prevalence, incidence, mortality and disability-adjusted life years (DALYs) of UCAs from 1990 to 2019 by sex, region, and socio-demographic Index (SDI) in 204 countries and territories. The disease burden of UCAs was also estimated attributable to each risk factor were estimated according to risk exposure. In 2019, UCAs caused 10,200 all-ages deaths (95% UI 7550–13,400). The combined global incidence rate was 8.38 per 1000 (95% UI 5.88–12.0) live births. The ASIR increased slightly, while the ASDR decreased from 1990 to 2019.The UCAs burden varies greatly depending on the development level and geographical location. The UCAs burden was significantly higher in men than in women, and the sex differences showed an enlarging trend. Health risks and issues, including pollution, child and maternal malnutrition, diet habits, unsafe sanitation and water source, were detected to be positively related to UCAs burden. Albeit the age-standardised prevalence, mortality, incidence, and DALYs of UCAs have decreased, they still cause a public health challenge worldwide. The high deaths and DALYs rates in low and low-middle SDI countries highlight the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for enhancing water safety, reducing pollution, and healthy diets are crucial steps in reducing the burden of UCAs.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Hubei Key Research and Development Program
Publisher
Springer Science and Business Media LLC
Reference53 articles.
1. Acharya, P. T., Ponrartana, S., Lai, L., Vasquez, E. & Goodarzian, F. Imaging of congenital genitourinary anomalies. Pediatr. Radiol. 52(4), 726–739 (2022).
2. Loane, M. et al. Paper 4: EUROCAT statistical monitoring: Identification and investigation of ten year trends of congenital anomalies in Europe. Birth Defects Res. A Clin. Mol. Teratol. 91(Suppl 1), S31–S43 (2011).
3. Isert, S., Muller, D. & Thumfart, J. Factors associated with the development of chronic kidney disease in children with congenital anomalies of the kidney and urinary tract. Front. Pediatr. 8, 298 (2020).
4. Hiort, O. et al. Management of disorders of sex development. Nat. Rev. Endocrinol. 10(9), 520–529 (2014).
5. Vos, T. et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet 396(10258), 1204–1222 (2020).