Abstract
AbstractChanges in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source optical coherence tomography angiography (SS-OCTA), and its relationship with the central visual field (VF) loss. Thirty-four eyes of 27 patients with open-angle glaucoma were included. SS-OCTA macular scanning was performed within a 3 × 3 mm (300 × 300 pixels) volume, centred on the fovea. The relationships between the vertical asymmetrical deep retinal vessel density reduction (ADRVD) across the temporal raphe and various ocular parameters were analysed. Twenty-two glaucomatous eyes with ADRVDs had central VF loss. Contrarily, ADRVDs were not found in any of the 12 eyes without central VF loss. Thirteen eyes (59.1%) with central VF loss had ADRVDs topographically corresponding to the central VF loss and macular ganglion cell complex thinning. The glaucomatous eyes with ADRVDs exhibited inferior rather than superior central VF loss (P = 0.032). Thus, ADRVD specifically indicates the glaucomatous central visual loss. Further analysis of ADRVD may improve our understanding on glaucoma pathogenesis, offering new treatment insights.
Funder
Daiwa Securities Health Foundation
Takeda Science Foundation
Japan Society for the Promotion of Science London
Grant-in-Aid for Young Researchers in Saitama Medical University Hospital
Allergan
Bausch and Lomb
Carl Zeiss Meditec AG
Genentech
Heidelberg Engineering
U.S. Department of Health & Human Services | NIH | National Eye Institute
Eyenovia, Optos, Optovue, Unity.
Publisher
Springer Science and Business Media LLC
Cited by
8 articles.
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