Author:
Baek Dong-Cheol,Kang Ji-Yun,Lee Jin-Seok,Lee Eun-Jung,Son Chang-Gue
Abstract
AbstractThe high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and depressive/amnesic behaviors. C57BL/6J female mice were ovariectomized (OVX) to establish a menopausal condition. Along with behavior tests (anxiety, depression, and memory), the expression of ERs, microglial activity, and neuronal activity was measured in six brain regions (hippocampus, prefrontal cortex, striatum, raphe nucleus, amygdala, and hypothalamus) from 4 to 12 weeks after OVX. Mice exhibited anxiety- and depressive-like behaviors, as well as memory impairment. These behavioral alterations have been linked to a suppression in the expression of ERβ. The decreased ERβ expression coincided with microglial-derived neuroinflammation, as indicated by notable activations of Ionized calcium-binding adapter molecule 1 and Interleukin-1beta. Additionally, the activity of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus, decreased in a time-dependent manner from 4 to 12 weeks post-OVX. Our study provides evidence shedding light on the susceptibility to memory impairment and depression in women after menopause. This susceptibility is associated with the suppression of ERβ and alteration of ERα in six brain regions.
Funder
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Reference61 articles.
1. Giorno, C. D. et al. Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause. Rev. Assoc. Méd. Brasil. 56, 558–562 (2010).
2. Harper, J. C. et al. An online survey of perimenopausal women to determine their attitudes and knowledge of the menopause. Womens Health 18, 17455057221106890 (2022).
3. Herson, M. & Kulkarni, J. Hormonal agents for the treatment of depression associated with the menopause. Drugs Aging 39, 607–618 (2022).
4. Mielke, M. M. Sex and gender differences in Alzheimer’s disease dementia. Psychiatric Times 35, 14 (2018).
5. Bustamante-Barrientos, F. A. et al. The impact of estrogen and estrogen-like molecules in neurogenesis and neurodegeneration: Beneficial or harmful?. Front. Cell. Neurosci. 15, 636176 (2021).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献