Author:
Yamaji Takayuki,Harada Takahiro,Hashimoto Yu,Nakano Yukiko,Kajikawa Masato,Yoshimura Kenichi,Chayama Kazuaki,Goto Chikara,Han Yiming,Mizobuchi Aya,Yusoff Farina Mohamad,Kishimoto Shinji,Maruhashi Tatsuya,Nakashima Ayumu,Higashi Yukihito
Abstract
AbstractWe divided the 466 subjects into two groups based on information on sitting time on a non-working day and evaluated flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID). FMD was smaller in subjects with sitting time on a non-working day of ≥6 h/day than in subjects with sitting time on a non-working day of <6 h/day (2.5 ± 2.6% vs. 3.7 ± 2.9%; p < 0.001). NID was smaller in subjects with sitting time at non-working day of ≥ 8 h/day than in subjects with sitting time on a non-working day of < 8 h/day (10.1 ± 5.6% vs. 11.5 ± 5.0%; p = 0.01). After adjustment for confounding factors for vascular function, the odds of having the lowest tertile of FMD was significantly higher in subjects with sitting time on a non-working day of ≥6 h/day than in subjects with sitting time on a non-working day of <6 h/day. The odds of having the lowest tertile of NID was significant higher in subjects with sitting time on a non-working day of ≥ 8 h/day than in subjects with sitting time on a non-working day of < 8 h/day. These findings suggest that prolonged sitting time on a non-working day is associated with blunted FMD and blunted NID.
Funder
Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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