A de novo substructure generation algorithm for identifying the privileged chemical fragments of liver X receptorβ agonists
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-08848-4.pdf
Reference46 articles.
1. Hong, C. & Tontonoz, P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nature reviews. Drug discovery 13, 433–444 (2014).
2. Lin, C.-Y., Vedin, L.-L. & Steffensen, K. R. The emerging roles of liver X receptors and their ligands in cancer. Expert Opinion on Therapeutic Targets 20, 61–71 (2016).
3. Zhao, W. et al. Three-dimensional pharmacophore modeling of liver-X receptor agonists. Journal of chemical information and modeling 51, 2147–2155 (2011).
4. Li, Y. et al. Predicting selective liver X receptor b agonists using multiple machine learning methods. Molecular BioSystems 11, 1241–1250 (2015).
5. Temml, V., Voss, C. V., Dirsch, V. M. & Schuster, D. Discovery of New Liver X Receptor Agonists by Pharmacophore Modeling and Shape-Based Virtual Screening. Journal of chemical information and modeling 54, 367–371 (2014).
Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Multi-constraint molecular generation using sparsely labelled training data for localized high-concentration electrolyte diluent screening;Digital Discovery;2023
2. Discovery of Spiro[pyrrolidine-3,3′-oxindole] LXRβ Agonists for the Treatment of Osteoporosis;Journal of Medicinal Chemistry;2022-12-20
3. Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach;Journal of Medicinal Chemistry;2021-02-05
4. Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay;European Journal of Medicinal Chemistry;2019-09
5. Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach;Journal of Medicinal Chemistry;2019-05-24
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3