Author:
Omotoso Adewunmi Omolade,Reyer Henry,Oster Michael,Ponsuksili Siriluck,Trakooljul Nares,Muráni Eduard,Sommerfeld Vera,Rodehutscord Markus,Wimmers Klaus
Abstract
AbstractThe jejunum plays crucial roles for the digestion and absorption of nutrients and minerals and for barrier functions that are essential for a healthy, productive life cycle of farm animals, including laying hens. Accordingly, knowledge of the molecular pathways that emerge in the intestine during development, and particularly at the beginning of laying activity, will help to derive strategies for improving nutrient efficiency in laying hens. In this study, jejunal samples were obtained from two high-yielding layer strains at five developmental stages (weeks 10, 16, 24, 30 and 60 of life) for RNA-sequencing, alongside the profiling of blood plasma parameters to approximate the dynamics of mineral homeostasis. The results reflected a marked distinction between the pre-laying and laying phase as inferred from levels of parathyroid hormone, triiodothyronine, estradiol, vitamin D, and calcium. Moreover, the expression patterns of the intestinal mucosa responded directly to the changing metabolic and nutritional profiles at the beginning of the laying phase in maturing high-yielding strains of laying hens. These comprise signaling events namely RANK/RANKL signaling and cellular senescence. Taken together, the timing of sexual maturity of laying hens demands closer examination to unravel metabolic requirements and associated endogenous mechanisms.
Funder
Deutsche Forschungsgemeinschaft
Leibniz-Institut für Nutztierbiologie
Publisher
Springer Science and Business Media LLC
Reference71 articles.
1. United Nations and Department of Economic and Social Affairs. World population prospects 2019. New York (UNDESA) (2019).
2. Shahbandeh, M. Global egg production from 1990 to 2018 (in 1000 metric tons). https://www.statista.com/statistics/263972/egg-production-worldwide-since-1990/ (2020).
3. FAOSTAT, 2020 http://www.fao.org/faostat/en/#compare
4. Bain, M. M., Nys, Y. & Dunn, I. C. Increasing persistency in lay and stabilizing egg quality in longer laying cycles. What are the challenges?. Br. Poult. Sci. 57, 330–338 (2016).
5. Fernyhough, M., Nicol, C. J., van de Braak, T., Toscano, M. J. & Tønnessen, M. The ethics of laying hen genetics. J. Agric. Environ. Ethics. 33, 15–36 (2020).
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献