Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats
Author:
Funder
Parkinson's UK
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-44803-1.pdf
Reference33 articles.
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3. Titova, N., Padmakumar, C., Lewis, S. J. G. & Chaudhuri, K. R. Parkinson’s: a syndrome rather than a disease? J Neural Transm (Vienna) 124, 907–914, https://doi.org/10.1007/s00702-016-1667-6 (2017).
4. Ohmachi, S. et al. FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain. Biochem Biophys Res Commun 277, 355–360, https://doi.org/10.1006/bbrc.2000.3675 (2000).
5. Grothe, C. et al. Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons. Neurobiol Dis 17, 163–170, https://doi.org/10.1016/j.nbd.2004.07.007 (2004).
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