Radiation makes cells select the form of death dependent on external or internal exposure: apoptosis or pyroptosis
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Published:2023-07-25
Issue:1
Volume:13
Page:
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ISSN:2045-2322
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Container-title:Scientific Reports
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language:en
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Short-container-title:Sci Rep
Author:
Shichijo Kazuko,Takatsuji Toshihiro,Uzbekov Darkhan,Chaizhunusova Nailya,Shabdarbaeva Dariya,Kurisu Minako,Takahashi Yoshio,Stepanenko Valeriy,Azhimkhanov Almas,Hoshi Masaharu
Abstract
AbstractInternal radiation exposure from neutron-induced radioisotopes environmentally activated following atomic bombing or nuclear accidents should be considered for a complete picture of pathologic effects on survivors. Acute and localized high dose radiation exposure from hot particles taken into the body must induce cell death and severe damage to tissues, whether they are proliferating or not. However, very little the cellular and molecular mechanisms underlying this internal radiation pathology has been investigated. Male Wistar rats were internally exposed to 56MnO2 powder by inhalation. Small intestine samples were investigated by histological staining at acute phase (6 h, 3 days and 14 days) and late phase (2, 6 and 8 months) after the exposure. Histological location and chemical properties of the hot particles embedded in small intestinal tissues were analyzed by synchrotron radiation—X-ray fluorescence—X-ray absorption near-edge structure (SR–XRF–XANES). Hot particles located in the intestinal cavity were identified as accumulations of Mn and iron. Pathological changes showed evidence of crypt shortening, massive cell death at the position of stem cell zone, including apoptosis and pyroptosis from 6 h through 8 months in the internal exposed rats.
Funder
Grants-in-Aid for Scientific Research
the Program of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University, Nagasaki University and Fukushima Medical University
the Semey State Medical University, Kazakhstan
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
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