Author:
Saito Yuki,Obokata Masaru,Harada Tomonari,Kagami Kazuki,Murata Makoto,Sorimachi Hidemi,Kato Toshimitsu,Wada Naoki,Okumura Yasuo,Ishii Hideki
Abstract
AbstractCardiopulmonary exercise testing (CPET) may potentially differentiate heart failure (HF) with preserved ejection fraction (HFpEF) from noncardiac causes of dyspnea (NCD). While contemporary guidelines for HF recommend using CPET for identifying causes of unexplained dyspnea, data supporting this practice are limited. This study aimed to determine the diagnostic value of expired gas analysis to distinguish HFpEF from NCD. Exercise stress echocardiography with simultaneous expired gas analysis was performed in patients with HFpEF (n = 116) and those with NCD (n = 112). Participants without dyspnea symptoms were also enrolled as controls (n = 26). Exercise capacity was impaired in patients with HFpEF than in controls and those with NCD, evidenced by lower oxygen consumption (VO2), but there was a substantial overlap between HFpEF and NCD. Receiver operating characteristic curve analyses showed modest diagnostic abilities of expired gas analysis data in differentiating individuals with HFpEF from the controls; however, none of these variables clearly differentiated between HFpEF and NCD (all areas under the curve < 0.61). Expired gas analysis provided objective assessments of exercise capacity; however, its diagnostic value in identifying HFpEF among patients with symptoms of exertional dyspnea was modest.
Funder
Fukuda Foundation for Medical Technology,Japan
Mochida Memorial Foundation for Medical and Pharmaceutical Research
Nippon Shinyaku
Takeda Science Foundation
Japanese Circulation Society
Japanese College of Cardiology
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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