Author:
Manchanda Sheetal,Sardana Divesh,Peng Simin,Lo Edward C. M.,Yiu Cynthia K. Y.
Abstract
AbstractWe compare the effect of calcium and phosphate-containing sodium fluoride (NaF) varnishes to conventional NaF varnish on S. mutans and L. fermentum counts. 3–4 years old children were grouped according to their caries status (n = 45 each): caries-free, with non-cavitated and with cavitated lesions. Each group was randomly subdivided (n = 15 each) into: Group 1- 5% NaF, Group 2- 5% NaF with tricalcium phosphate, Group 3- 5% NaF with casein phosphopeptide- amorphous calcium phosphate. Biofilm and saliva were collected to quantify microorganisms at baseline (T1) and 24-months (T2). Differences between groups were compared using Kruskal–Wallis test, followed by Dunn-Bonferroni post-test, at 0.0167 α-level. Significant difference was found for percentage of children with detectable biofilm L. fermentum (p = 0.013) at T1 and salivary S. mutans (p = 0.011) at T2. Percentage of children increased from T1 to T2 in Group 2 with salivary S. mutans (p = 0.007), salivary L. fermentum (p = 0.035), and biofilm L. fermentum (p = 0.019) and in Group 3 with salivary L. fermentum (p = 0.035). Bacterial change was not significant in both samples of intervention groups, except increase in salivary S. mutans (p = 0.038) in Group 3. Both calcium- and phosphate-containing NaF varnishes demonstrated similar antibacterial effect on S. mutans and L. fermentum compared to conventional NaF varnish.
Funder
Research Grants Council, Hong Kong
Publisher
Springer Science and Business Media LLC
Reference42 articles.
1. Seow, W. K. Early childhood caries. Pediatr. Clin. North Am. 65, 941–954 (2018).
2. GBD 2017 Oral Disorders Collaborators, Bernabe, E. et al. Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study. J. Dent. Res. 99, 362–373 (2020).
3. Nyvad, B. & Baelum, V. Nyvad criteria for caries lesion activity and severity assessment: a validated approach for clinical management and research. Caries Res. 52, 397–405 (2018).
4. Erkmen Almaz, M. & Akbay Oba, A. Antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries: a randomised controlled trial. Clin. Oral Investig. 24, 2129–2136 (2020).
5. Paek, A. E. et al. Caries outcome following an intensive fluoride varnish treatment regimen for children at high risk for early childhood caries. Int. J. Paediatr. Dent. 28, 291–299 (2018).