Author:
Chevala Naga Thirumalesh,Kumar Lalit,Veetilvalappil Vimal,Mathew Aranjani Jesil,Paonam Bemma,Mohan Ganesh,Shastry Shamee,Balasubramanian Krishnan,Rao C. Mallikarjuna
Abstract
AbstractUnmanageable bleeding is one of the significant causes of mortality. Attaining rapid hemostasis ensures subject survivability as a first aid during combats, road accidents, surgeries that reduce mortality. Nanoporous fibers reinforced composite scaffold (NFRCS) developed by a simple hemostatic film-forming composition (HFFC) (as a continuous phase) can trigger and intensify hemostasis. NFRCS developed was based on the dragonfly wing structure's structural design. Dragonfly wing structure consists of cross-veins and longitudinal wing veins inter-connected with wing membrane to maintain the microstructural integrity. The HFFC uniformly surface coats the fibers with nano thickness film and interconnects the randomly distributed cotton gauge (Ct) (dispersed phase), resulting in the formation of a nanoporous structure. Integrating continuous and dispersed phases reduce the product cost by ten times that of marketed products. The modified NFRCS (tampon or wrist band) can be used for various biomedical applications. The in vivo studies conclude that the developed Cp NFRCS triggers and intensifies the coagulation process at the application site. The NFRCS could regulate the microenvironment and act at the cellular level due to its nanoporous structure, which resulted in better wound healing in the excision wound model.
Funder
Indian Council of Medical Research
Publisher
Springer Science and Business Media LLC
Reference71 articles.
1. Feskov, A. E., Sokolov, A. S. & Soloshenko, S. V. New hemostatic bandages based on a natural biopolymer chitosan. Emerg. Med. 0, 95–98 (2017).
2. De Carvalho, M. V. H. et al. Agentes hemostáticos locais e adesivos teciduais. Rev. Col. Bras. Cir. 40, 66–71 (2013).
3. Zhang, L. et al. Prevention and management of hemorrhage during a laparoscopic colorectal surgery. Ann. Laparosc. Endosc. Surg. 1, 40–40 (2016).
4. Kirkman, E. & Watts, S. Haemodynamic changes in trauma. Br. J. Anaesth. 113, 266–275 (2014).
5. Walters, T. J. & Mabry, R. L. Issues related to the use of tourniquets on the battlefield. Mil. Med. 170, 770–775 (2005).
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