Author:
Boscato Noéli,Exposto Fernando G.,Costa Yuri M.,Svensson Peter
Abstract
AbstractRecently, it has been proposed that bruxism could represent an overlearned behavior due to the absence of corticomotor plasticity following a relevant tooth-clenching task (TCT). This study assessed the modulatory effects of a nerve growth factor (NGF) injection on masseter muscle corticomotor excitability, jaw motor performance, pain, and limitation in bruxer and control participants following a TCT. Participants characterized as definitive bruxers or controls were randomly assigned to have injected into the right masseter muscle either NGF or isotonic saline (IS), resulting in a study with 4 arms: IS_Control (n = 7), IS_Bruxer (n = 7); NGF_Control (n = 6), and NGF_Bruxer (n = 8). The primary outcome was the masseter motor evoked potential (MEP) amplitude measured at baseline and after a TCT. After the interventions, significantly higher and lower MEP amplitude and corticomotor map area were observed, respectively, in the IS_Control and NGF_Control groups (P < 0.05). Precision and accuracy depended on the series and target force level with significant between-group differences (P < 0.01). NGF‐induced masseter muscle sensitization, in combination with a training-induced effect, can significantly impact the corticomotor excitability of the masseter muscle in control participants indicating substantial changes in corticomotor excitability, which are not observed in bruxers. These preliminary findings may have therapeuthic implications for the potential to “detrain” and manage bruxism, but further studies with larger sample sizes will be needed to test this new concept.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil
Publisher
Springer Science and Business Media LLC
Reference43 articles.
1. Svensson, P., Jadidi, F., Arima, T., Baad-Hansen, L. & Sessler, B. J. Relationships between craniofacial pain and bruxism. J. Oral Rehabil. 35, 524–547 (2008).
2. Baad-Hansen, L., Thymi, M., Lobbezoo, F. & Svensson, P. To what extent is bruxism associated with musculoskeletal signs and symptoms? A systematic review. J. Oral Rehabil. 46, 845–861 (2019).
3. Lobbezoo, F. et al. International consensus on the assessment of bruxism: Report of a work in progress. J. Oral Rehabil. 45, 837–844 (2018).
4. Svensson, P., Arima, T., Lavigne, G. & Castrillon, E. Sleep bruxism: definition, prevalence, classification, etiology, and consequences. In Principles and Practice of Sleep Medicine (eds Kryger, M. et al.) 1423–1426 (Elsevier, 2020).
5. Svensson, P., Cairns, B. E., Wang, K. & Arendt-Nielsen, L. Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia. Pain 104, 241–247 (2003).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献