Author:
Shahtalebi Soroosh,Atashzar S. Farokh,Patel Rajni V.,Jog Mandar S.,Mohammadi Arash
Abstract
AbstractPathological hand tremor (PHT) is a common symptom of Parkinson’s disease (PD) and essential tremor (ET), which affects manual targeting, motor coordination, and movement kinetics. Effective treatment and management of the symptoms relies on the correct and in-time diagnosis of the affected individuals, where the characteristics of PHT serve as an imperative metric for this purpose. Due to the overlapping features of the corresponding symptoms, however, a high level of expertise and specialized diagnostic methodologies are required to correctly distinguish PD from ET. In this work, we propose the data-driven $$\text {NeurDNet}$$
NeurDNet
model, which processes the kinematics of the hand in the affected individuals and classifies the patients into PD or ET. $$\text {NeurDNet}$$
NeurDNet
is trained over 90 hours of hand motion signals consisting of 250 tremor assessments from 81 patients, recorded at the London Movement Disorders Centre, ON, Canada. The $$\text {NeurDNet}$$
NeurDNet
outperforms its state-of-the-art counterparts achieving exceptional differential diagnosis accuracy of $$95.55\%$$
95.55
%
. In addition, using the explainability and interpretability measures for machine learning models, clinically viable and statistically significant insights on how the data-driven model discriminates between the two groups of patients are achieved.
Funder
Natural Sciences and Engineering Research Council of Canada
Publisher
Springer Science and Business Media LLC
Reference63 articles.
1. Nations, U. World Population Prospects, The 2017 Revision, Volume I: Comprehensive Tables (Department of Economics and Social Affairs, Population Devision, 2017).
2. Wooten, G., Currie, L., Bovbjerg, V., Lee, J. & Patrie, J. Are men at greater risk for Parkinson’s disease than women?. J. Neurol. Neurosurg. Psychiatry 75, 637–639 (2004).
3. Launer, L. et al. Prevalence of Parkinson’s disease in Europe: A collaborative study of population-based cohorts. neurologic diseases in the elderly research group. Neurology 54, s21-3 (2000).
4. Louis, E. D. & Ferreira, J. J. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov. Disord. 25, 534–541 (2010).
5. Hammond, C., Bergman, H. & Brown, P. Pathological synchronization in Parkinson’s disease: Networks, models and treatments. Trends Neurosci. 30, 357–364 (2007).
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