Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides-Reference-Cited by-同舟云学术

Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

Published:2021-01-22 Issue:1 Volume:11 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Hua Ting-Bi,Liu Cheng-Xiong,Hu Wei-Min,Wang Long,Yang Qing-Qing

Abstract

AbstractAn efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.

Funder

National Natural Science Foundation of China

the 111 project

Open fund from Hubei Key Laboratory of Natural Products Research and Development of China Three Gorges University

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-021-81370-w.pdf

Reference50 articles.

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