Author:
Kunisaki Atsushi,Kodama Akira,Ishikawa Masakazu,Ueda Takahiro,Lima Marcio D.,Kondo Takeshi,Adachi Nobuo
Abstract
AbstractCarbon nanotubes (CNTs) have the potential to promote peripheral nerve regeneration, although with limited capacity and foreign body reaction. This study investigated whether CNTs hydrophilized by oxidation can improve peripheral nerve regeneration and reduce foreign body reactions and inflammation. Three different artificial nerve conduit models were created using CNTs treated with ozone (O group), strong acid (SA group), and untreated (P group). They were implanted into a rat sciatic nerve defect model and evaluated after 8 and 16 weeks. At 16 weeks, the SA group showed significant recovery in functional and electrophysiological evaluations compared with the others. At 8 weeks, histological examination revealed a significant increase in the density of regenerated neurofilament and decreased foreign body giant cells in the SA group compared with the others. Oxidation-treated CNTs improved biocompatibility, induced nerve regeneration, and inhibited foreign-body reactions.
Funder
JSPS KAKENHI
Tuchiya Memorial Medical Foundation
Takeda Science Foundation
Publisher
Springer Science and Business Media LLC