Author:
Sakurai Miyuki,Motoike Ikuko N.,Hishinuma Eiji,Aoki Yuichi,Tadaka Shu,Kogure Mana,Orui Masatsugu,Ishikuro Mami,Obara Taku,Nakaya Naoki,Kumada Kazuki,Hozawa Atsushi,Kuriyama Shinichi,Yamamoto Masayuki,Koshiba Seizo,Kinoshita Kengo
Abstract
AbstractUnderstanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55–59 to 60–64 years being a period of significant metabolic change, particularly in men, and from 45–49 to 50–54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
B-Cure from Japan Agency for Medical Research and Development
Ministry of Education, Culture, Sports, Science and Technology.The Project for Promoting Public Utilization of Advanced Research Infrastructure
Ministry of Education, Culture, Sports, Science, and Technology. The Sharing and Administrative Network for Research Equipment
Japan Science and Technology Agency. Center of Innovation Program
Publisher
Springer Science and Business Media LLC