Author:
Shih Nai-Chen,Kung Pei-Tseng,Kuo Wei-Yin,Tsai Wen-Chen
Abstract
AbstractBreast cancer is the fifth leading cause of cancer death globally. In this retrospective study, we investigated the effects of the diagnosis-to-first-treatment interval (DFTI) and other related factors on cancer-specific survival in patients with breast cancer. We included 49,426 patients newly diagnosed as having breast cancer during 2011–2017. The Cox proportional hazards model was used to analyze the hazard ratio (HR) for mortality with various DFTIs; the HRs of the 31–60-, 61–90-, and ≥ 91-day DFTI groups did not differ significantly compared with the reference group (DFTI ≤ 30 days). After stratifying the patients according to initial tumor stage and age, we found that patients aged 55–64 and ≥ 65 years with stage II breast cancer treated ≥ 91 days after diagnosis had a 3.34- and 2.93-fold higher mortality risk (95% confidence intervals [CIs] 1.29–8.69 and 1.06–8.10, respectively). Patients aged ≥ 65 years with stage IV breast cancer treated within 61–90 or ≥ 91 days after diagnosis had a 7.14- and 34.78-fold higher mortality risk (95% CIs 1.28–39.82 and 3.08–393.32, respectively). In conclusion, DFTI is associated with mortality in patients with stage II and IV breast cancer, especially at an older age.
Funder
China Medical University and Asia University
the Ministry of Science and Technology, Taiwan
Publisher
Springer Science and Business Media LLC
Reference27 articles.
1. International Agency for Research on Cancer. (2020). W. H. O. Breast. Accessed 30 June 2021 from https://reurl.cc/AKWV73.
2. Cancer Registry Annual Report, 2019 Taiwan 5 (Health Promotion Administration, Ministry of Health and Welfare, 2021).
3. Cancer Stat Facts: Female Breast Cancer. Accessed 21 July 2021 from https://reurl.cc/zMR78N.
4. Chen, S. J., Kung, P. T., Huang, K. H., Wang, Y. H. & Tsai, W. C. Characteristics of the delayed or refusal therapy in breast cancer patients: A longitudinal population-based study in Taiwan. PLoS ONE 10, e0131305. https://doi.org/10.1371/journal.pone.0131305 (2015).
5. Jung, S. Y. et al. The effect of delays in treatment for breast cancer metastasis on survival. Breast Cancer Res. Treat. 130, 953–964. https://doi.org/10.1007/s10549-011-1662-4 (2011).
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