Author:
Zambach Christian,Pan Jingxue,Gerward Sofia,Fedorowski Artur,Smith J. Gustav,Engström Gunnar,Hamrefors Viktor
Abstract
AbstractWhereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swedish CardioPulmonary bioImage Study with information on smoking habits, diabetes, antihypertensive drug treatment, anthropometrics, hemodynamic measurements and 818 plasma metabolites (mass-spectrometry). The associations between each metabolite and orthostatic systolic blood pressure responses were determined using multivariable linear regression analysis and p values were corrected using the Bonferroni method. Six amino acids, five vitamins, co-factors and carbohydrates, nine lipids and two xenobiotics were associated with orthostatic blood pressure after adjusting for age, gender and systolic blood pressure. After additional adjustments for BMI, diabetes, smoking and antihypertensive treatment, the association remained significant for six lipids, four amino acids and one xenobiotic. Twenty-two out of 818 plasma metabolites were associated with orthostatic blood pressure responses. Eleven metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after additional adjustment for markers of cardio-metabolic disease.
Funder
the Swedish Heart-Lung Foundation
the Swedish Research Council
the European Research Council
governmental funding of clinical research within the Swedish National Health Service
the Skåne University hospital at the ALF (Avtal om Läkarutbildning och Forskning) agreement
the Medical Faculty of Lund University
Skåne University Hospital Funds
Crafoord Foundation
Ernhold Lundströms Research Foundation
Region Skåne
Hulda and Conrad Mossfelt Foundation
Anna-Lisa and Sven Eric Lundgrens Foundation for Medical Research
Lund University
Publisher
Springer Science and Business Media LLC