Author:
Okemoto-Nakamura Yuko,Someya Kenji,Yamaji Toshiyuki,Saito Kyoko,Takeda Makoto,Hanada Kentaro
Abstract
AbstractPolio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except for limited regions. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting the third edition of the Global Action Plan, which is requesting stringent control of potentially PV-infected materials. To facilitate the mission, we generated a PV-nonsusceptible Vero cell subline, which may serve as an ideal replacement of standard Vero cells to isolate emerging/re-emerging viruses without the risk of generating PV-infected materials.
Funder
TERUMO LIFE SCIENCE FOUNDATION
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Reference27 articles.
1. Nomoto, A., Koike, S. & Aoki, J. Tissue tropism and species specificity of poliovirus infection. Trends Microbiol. 2, 47–51. https://doi.org/10.1016/0966-842x(94)90125-2 (1994).
2. Alonge, O. What can over 30 years of efforts to eradicate polio teach us about global health?. BMC Public Health 20(2), 1177. https://doi.org/10.1186/s12889-020-09198-z (2020).
3. Shaghaghi, M. et al. New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data. Vaccine 36, 1711–1719. https://doi.org/10.1016/j.vaccine.2018.02.059 (2018).
4. Macklin, G. R. et al. Evolving epidemiology of poliovirus serotype 2 following withdrawal of the serotype 2 oral poliovirus vaccine. Science 368, 401–405. https://doi.org/10.1126/science.aba1238 (2020).
5. The World Health Organization. WHO Global Action Plan to Minimize Poliovirus Facility-Associated Risk After Type-Specific Eradication of Wild Polioviruses and Sequential Cessation of Oral Polio Vaccine Use (WHO Press, Cleveland, 2015).
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