Author:
Zaer Hamed,Glud Andreas Nørgaard,Schneider Bret M.,Lukacova Slávka,Vang Hansen Kim,Adler John R.,Høyer Morten,Jensen Morten Bjørn,Hansen Rune,Hoffmann Lone,Worm Esben Schjødt,Sørensen Jens Chr. Hedemann,Orlowski Dariusz
Abstract
AbstractStereotactic radiosurgery (SRS) has proven an effective tool for the treatment of brain tumors, arteriovenous malformation, and functional conditions. However, radiation-induced therapeutic effect in viable cells in functional SRS is also suggested. Evaluation of the proposed modulatory effect of irradiation on neuronal activity without causing cellular death requires the knowledge of radiation dose tolerance at very small tissue volume. Therefore, we aimed to establish a porcine model to study the effects of ultra-high radiosurgical doses in small volumes of the brain. Five minipigs received focal stereotactic radiosurgery with single large doses of 40–100 Gy to 5–7.5 mm fields in the left primary motor cortex and the right subcortical white matter, and one animal remained as unirradiated control. The animals were followed-up with serial MRI,
PET scans, and histology 6 months post-radiation. We observed a dose-dependent relation of the histological and MRI changes at 6 months post-radiation. The necrotic lesions were seen in the grey matter at 100 Gy and in white matter at 60 Gy. Furthermore, small volume radiosurgery at different dose levels induced vascular, as well as neuronal cell changes and glial cell remodeling.
Funder
Zap Surgical Systems, Inc., San Carlos, California, USA
Publisher
Springer Science and Business Media LLC
Cited by
11 articles.
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