The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-27233-3.pdf
Reference47 articles.
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2. Christopoulos, P. F., Msaouel, P. & Koutsilieris, M. The role of the insulin-like growth factor-1 system in breast cancer. Mol Cancer 14, 43, https://doi.org/10.1186/s12943-015-0291-7 (2015).
3. Barton, E. R. The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repair. Appl Physiol Nutr Metab 31, 791–797, https://doi.org/10.1139/h06-054 (2006).
4. Philippou, A., Maridaki, M., Pneumaticos, S. & Koutsilieris, M. The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity. Mol Med 20, 202–214, https://doi.org/10.2119/molmed.2014.00011 (2014).
5. Annibalini, G. et al. MIR retroposon exonization promotes evolutionary variability and generates species-specific expression of IGF-1 splice variants. Biochim Biophys Acta 1859, 757–768, https://doi.org/10.1016/j.bbagrm.2016.03.014 (2016).
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