Alleles of a gene differ in pleiotropy, often mediated through currency metabolite production, in E. coli and yeast metabolic simulations
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-35092-1.pdf
Reference49 articles.
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2. Wagner, G. P. & Zhang, J. The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nat Rev Genet 12, 204–213 (2011).
3. Paul, D. A double-edged sword. Nature 405, 515–515 (2000).
4. Williams, G. C. Pleiotropy, Natural-Selection, and the Evolution of Senescence. Evolution 11, 398–411 (1957).
5. Zwaan, B. J. The evolutionary genetics of ageing and longevity. Heredity 82, 589–597 (1999).
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