Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers

Author:

Aragón-Herrera Alana,Couselo-Seijas Marinela,Feijóo-Bandín Sandra,Anido-Varela Laura,Moraña-Fernández Sandra,Tarazón Estefanía,Roselló-Lletí Esther,Portolés Manuel,Martínez-Sande José Luis,García-Seara Javier,Álvarez Ezequiel,González-Juanatey José Ramón,Rodríguez-Mañero Moisés,Eiras Sonia,Lago Francisca

Abstract

AbstractRelaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal processes in the pathogenesis of AF, our aim was to study the relationship between relaxin-2 plasma levels in left atrium (LA) and peripheral vein with molecules implicated in fibrosis, inflammation and oxidative stress in AF patients, and to evaluate the anti-fibrotic ability of relaxin-2 in normal human atrial cardiac fibroblasts (NHCF-A). Peripheral vein relaxin-2 plasma levels were higher than LA relaxin-2 plasma levels in men while, in women, peripheral vein relaxin-2 levels were increased compared to men. AF patients with higher levels of relaxin-2 exhibited a reduction in H2O2 plasma levels and in mRNA levels of alpha-defensin 3 (DEFA3) and IL-6 in leucocytes from LA plasma. Relaxin-2-in-vitro treatment inhibited NHCF-A migration and decreased mRNA and protein levels of the pro-fibrotic molecule transforming growth factor-β1 (TGF-β1). Our results support an association between relaxin-2 and molecules involved in fibrosis, inflammation and oxidative stress in AF patients, and reinforce an anti-fibrotic protective role of this hormone in NHCF-A; strengthening the relevance of relaxin-2 in AF physiopathology, diagnosis and treatment.

Funder

Spanish Society of Cardiology

Predoctoral Research Grants from GAIN-Xunta de Galicia

Predoctoral Research Grants from FPU Program of the Spanish Ministry of Science, Innovation and Universities

Predoctoral Research Grants from Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)

National Institute of Health “Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III (ISCIII)” Madrid, Spain

Predoctoral Research Grants from the Spanish PFIS Program of the Instituto de Salud Carlos III (ISCIII)

European Regional Development Fund (FEDER) and European Union framework MSCA-RISE-H2020 Programme

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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