CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function-Reference-Cited by-同舟云学术

CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function

Published:2018-07-04 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Chen Yang,Chen Shu,Gu Yong,Feng Yingjie,Shi Yun,Fu Qi,Wang Zhixiao,Cai Yun,Dai Hao,Zheng Shuai,Sun Min,Zhang Mei,Xu Xinyu,Chen Heng,Xu Kuanfeng,Yang Tao

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-28423-9.pdf

Reference42 articles.

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2. Pentcheva-Hoang, T., Corse, E. & Allison, J. P. Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections. Immunol. Rev 229, 67–87 (2009).

3. Walker, L. S. & Sansom, D. M. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat. Rev. Immunol. 11, 852–863 (2011).

4. Olde Nordkamp, M. J., Koeleman, B. P. & Meyaard, L. Do inhibitory immune receptors play a role in the etiology of autoimmune disease? Clin. Immunol. 150, 31–42 (2014).

5. Wing, K. et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 322, 271–275 (2008).

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