Author:
Kim Hyunho,Hong Sung-Hee,Jeong Hyo Eun,Han Sewoon,Ahn Jinchul,Kim Jin-A.,Yang Ji-Hun,Oh Hyun Jeong,Chung Seok,Lee Sang-Eun
Abstract
AbstractThe protozoan parasiteToxoplasma gondii(T. gondii) causes one of the most common human zoonotic diseases and infects approximately one-third of the global population.T. gondiiinfects nearly every cell type and causes severe symptoms in susceptible populations. In previous laboratory animal studies,T. gondiimovement and transmission were not analyzed in real time. In a three-dimensional (3D) microfluidic assay, we successfully supported the complex lytic cycle ofT. gondiiin situ by generating a stable microvasculature. The physiology of theT. gondii-infected microvasculature was monitored in order to investigate the growth, paracellular and transcellular migration, and transmission ofT. gondii, as well as the efficacy ofT. gondiidrugs.
Funder
National Research Foundation of Korea
the Korea Evaluation Institute of Industrial Technology
Publisher
Springer Science and Business Media LLC
Reference62 articles.
1. Saadatnia, G. & Golkar, M. A review on human toxoplasmosis. Scand. J. Infect. Dis. 44, 805–814 (2012).
2. Jones, J. L. & Dubey, J. P. Foodborne toxoplasmosis. Clin. Infect. Dis. 55, 845–851 (2012).
3. De Moura, L. et al. Waterborne toxoplasmosis, Brazil, from field to gene. Emerg. Infect. Dis. 12, 326–329 (2006).
4. Joynson, D. H. M. & Wreghitt, T. G. Toxoplasmosis: A Comprehensive Clinical Guide (Cambridge University Press, Cambridge, 2005).
5. Montoya, J. G. & Liesenfeld, O. Toxoplasmosis. Lancet 363, 1965–1976 (2004).
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