Survival rate and predictors of mortality among TB/HIV co-infected adult patients: retrospective cohort study

Author:

Lelisho Mesfin EsayasORCID,Wotale Teramaj Wongel,Tareke Seid Ali,Alemu Bizuwork Derebew,Hassen Sali Suleman,Yemane Daniel Melese,Korsa Birhanu Bedada,Bedaso Namso Geda

Abstract

AbstractNowadays, Tuberculosis remains the major cause of HIV-associated mortality, which accounts for 1 out of every 5 HIV-related mortality worldwide. This study aimed to determine the survival rate and predictors of mortality among TB/HIV co-infected patients. An institution-based retrospective cohort study was undertaken on adult TB/HIV co-infected individuals between 1st February 2014 and 30th January 2022 at Mettu Karl Referral Hospital. A Cox regression model was used to identify predictors of survival time to death among TB/HIV co-infected patients. This study comprised 402 TB and HIV co-infected adult patients. Among these, 84 (20.9%) died, and 318 (79.1%) were censored. The study subjects have been followed up for 6920 person-months with an overall median survival time of 17.6 months. The overall incidence rate was 12.1 per 1000 person months [95% CI: 9.77–14.98]. The results of a multivariable Cox regression analysis showed that being at an older age, urban residence, WHO clinical stage II & IV, CD4 count of ≥ 200 cells/mm3, bedridden functional status, using INH, and using CPT were associated with the survival time of TB and HIV co-infected patients at a significance level of alpha = 0.05. This retrospective study found that high mortality of TB/HIV co-infected patients occurred in the earlier months of treatment initiation. Close monitoring of patients with low CD4, who do not utilize CPT, who are in advanced WHO stages, and who have poor functional levels can help them improve their health and live longer.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference55 articles.

1. Tola, A., Mishore, K. M., Ayele, Y., Mekuria, A. N. & Legese, N. Treatment outcome of tuberculosis and associated factors among TB-HIV Co-infected patients at public hospitals of Harar town, Eastern Ethiopia. A five-year retrospective study. BMC Public Health 19, 1–12 (2019).

2. Mugusi, F. M. et al. Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health 9, 1–8 (2009).

3. Gezae, K. E., Abebe, H. T., Gebretsadik, L. G. & Gebremeskel, A. K. Predictors of time to death among TB/HIV co-infected adults on ART at two governmental hospitals in Mekelle, Ethiopia, 2009–2016: A retrospective cohort study. Ann. Infect. Dis. Epidemiol. 2020(5), 1049 (2020).

4. Wondimu, W., Dube, L. & Kabeta, T. Factors affecting survival rates among adult TB/hiv co-infected patients in Mizan Tepi University teaching hospital, South West Ethiopia. HIV/AIDS (Auckland, NZ) 12, 157 (2020).

5. Kwan, C. K. & Ernst, J. D. HIV and tuberculosis: A deadly human syndemic. Clin. Microbiol. Rev. 24, 351–376 (2011).

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