Mosquitocidal effect of ivermectin-treated nettings and sprayed walls on Anopheles gambiae s.s.

Author:

Hamid-Adiamoh Majidah,Muhammad Abdul Khalie,Assogba Benoit Sessinou,Soumare Harouna Massire,Jadama Lamin,Diallo Moussa,D’Alessandro Umberto,Ousmane Ndiath Mamadou,Erhart Annette,Amambua-Ngwa Alfred

Abstract

AbstractIvermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle. Nevertheless, IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls. The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment. Laboratory-reared, insecticide-susceptible Kisumu Anopheles gambiae were exposed to IVM on impregnated netting materials and sprayed plastered- and mud walls using cone bioassays. The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM. The effect was slower on the IVM-sprayed walls compared to the treated nettings. Further work to evaluate possibility of IVM as a new insecticide formulation in LLINs and IRS will be required.

Funder

Wellcome’s Institutional Strategic Support Fund and London School of Hygiene & Tropical Medicine

Pan-African Malaria Genetics

Publisher

Springer Science and Business Media LLC

Reference42 articles.

1. WHO. World Malaria Report. World Health Organ. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2023. (2023).

2. WHO. Global Malaria Programme. Global technical strategy for malaria, 2016–2030, 2021 update. World Health Organ, https://www.who.int/publications/i/item/9789240031357. (2021).

3. Bhatt, S. et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526, 207–211 (2015).

4. Davies, T. G., Field, L. M., Usherwood, P. N. & Williamson, M. S. DDT, pyrethrins, pyrethroids and insect sodium channels. IUBMB Life 59, 151–162 (2007).

5. Fukuto, T. R. Mechanism of action of organophosphorus and carbamate insecticides. Environ. Health Perspect. 87, 245–254 (1990).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3