Author:
Hamid-Adiamoh Majidah,Muhammad Abdul Khalie,Assogba Benoit Sessinou,Soumare Harouna Massire,Jadama Lamin,Diallo Moussa,D’Alessandro Umberto,Ousmane Ndiath Mamadou,Erhart Annette,Amambua-Ngwa Alfred
Abstract
AbstractIvermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle. Nevertheless, IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls. The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment. Laboratory-reared, insecticide-susceptible Kisumu Anopheles gambiae were exposed to IVM on impregnated netting materials and sprayed plastered- and mud walls using cone bioassays. The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM. The effect was slower on the IVM-sprayed walls compared to the treated nettings. Further work to evaluate possibility of IVM as a new insecticide formulation in LLINs and IRS will be required.
Funder
Wellcome’s Institutional Strategic Support Fund and London School of Hygiene & Tropical Medicine
Pan-African Malaria Genetics
Publisher
Springer Science and Business Media LLC
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