Author:
Aiewsakun Pakorn,Ruangchai Wuthiwat,Thawornwattana Yuttapong,Jaemsai Bharkbhoom,Mahasirimongkol Surakameth,Homkaew Anchalee,Suksomchit Paveesuda,Dubbs Padungsri,Palittapongarnpim Prasit
Abstract
AbstractStreptococcus agalactiae, also known as Lancefield Group BStreptococcus(GBS), is typically regarded as a neonatal pathogen; however, several studies have shown that the bacteria are capable of causing invasive diseases in non-pregnant adults as well. The majority of documented cases were from Southeast Asian countries, and the most common genotype found was ST283, which is also known to be able to infect fish. This study sequenced 12 GBS ST283 samples collected from adult patients in Thailand. Together with publicly available sequences, we performed temporo-spatial analysis and estimated population dynamics of the bacteria. Putative drug resistance genes were also identified and characterized, and the drug resistance phenotypes were validated experimentally. The results, together with historical records, draw a detailed picture of the past transmission history of GBS ST283 in Southeast Asia.
Funder
Mahidol University
National Science and Technology Development Agency
Publisher
Springer Science and Business Media LLC
Reference56 articles.
1. Eickhoff, T. C., Klein, J. O., Daly, A. K., Ingall, D. & Finland, M. Neonatal sepsis and other infections due to group B beta-hemolytic streptococci. N. Engl. J. Med. 271, 1221–1228 (1964).
2. Kexel, G. & Schönbohm, S. Streptococcus agalactiae as a cause of meningitis in the newborn (report of three cases). Dtsch. Med. Wochenschrift 90, 258–261 (1965).
3. Meyn, L. A., Krohn, M. A. & Hillier, S. L. Rectal colonization by Group B Streptococcus as a predictor of vaginal colonization. Am. J. Obs. Gynecol. 201(76), e1-76.e7 (2009).
4. Skoff, T. H. et al. Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990–2007. Clin. Infect. Dis. 49, 85–92 (2009).
5. Lamagni, T. L. et al. Emerging trends in the epidemiology of invasive group B streptococcal disease in England and Wales, 1991–2010. Clin. Infect. Dis. 57, 682–688 (2013).
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献