Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity-Reference-Cited by-同舟云学术

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Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

Published:2017-11-22 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Forootan Shiva S.,Mutter Fiona E.,Kipar Anja,Iwawaki Takao,Francis Ben,Goldring Christopher E.,Park B. Kevin,Copple Ian M.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-16491-2.pdf

Reference26 articles.

1. Temple, R. J. & Himmel, M. H. Safety of newly approved drugs: implications for prescribing. JAMA 287, 2273–2275 (2002).

2. Andersen, M. E. & Krewski, D. The vision of toxicity testing in the 21st century: moving from discussion to action. Toxicol Sci 117, 17–24, https://doi.org/10.1093/toxsci/kfq188 (2010).

3. Huang, R. et al. Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization. Nat Commun 7, 10425, https://doi.org/10.1038/ncomms10425 (2016).

4. Wink, S. et al. Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment. Chem Res Toxicol 27, 338–355, https://doi.org/10.1021/tx4004038 (2014).

5. Ma, Q. Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53, 401–426, https://doi.org/10.1146/annurev-pharmtox-011112-140320 (2013).

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