GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

Author:

Lang Frederick M.ORCID,Lee Kevin M.-C.ORCID,Teijaro John R.,Becher BurkhardORCID,Hamilton John A.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Energy Engineering and Power Technology,Fuel Technology

Reference98 articles.

1. Zhou, Y. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci. Rev. https://doi.org/10.1093/nsr/nwaa041 (2020).

2. Hamilton, J. A. GM-CSF in inflammation. J. Exp. Med. 217, e20190945 (2020).

3. Hamilton, J. A., Cook, A. D. & Tak, P. P. Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nat. Rev. Drug. Discov. 16, 53–70 (2016).

4. Humanigen. FDA approves initiation of Humanigen’s phase III study of lenzilumab in COVID-19 patients. Humanigen https://www.humanigen.com/press/FDA-Approves-Initiation-of-Humanigen%E2%80%99s-Phase-III-Study-of-Lenzilumab-in-COVID-19-Patients (2020).

5. I-Mab Biopharma. I-Mab announces IND clearance from FDA for TJM2 to treat cytokine release syndrome (CRS) associated with severe coronavirus disease 19 (COVID-19). I-Mab Biopharma http://www.i-mabbiopharma.com/en/article-517.aspx (2020).

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