An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

Author:

Du Yan Shi,Fu Jin,Soto Claudio,Chen Xi,Zhu Huaijie,Al-Mohanna Futwan,Collison Kate,Zhu Aiping,Stern Eric,Saido Takaomi,Tohyama Masaya,Ogawa Satoshi,Roher Alex,Stern David

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference50 articles.

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2. Yankner, B. et al. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417–420 (1989).

3. Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864–869 (1996).

4. Roses, A. From genes to mechanisms to therapies: lessons to be learned for neurological disorders. Nature Med. 2, 267–269 (1996).

5. Cai, X., Golde, T. & Younkin, S. Release of excess amyloid β rotein from a mutant amyloid β protein precursor. Science 259, 514–516 (1993).

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