Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells

Author:

Lunde Elin,Munthe Ludvig A.,Vabø Anita,Sandlie Inger,Bogen Bjarne

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference41 articles.

1. Constant, S.L. & Bottomly, K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15, 297–322 ( 1997).

2. Snider, D.P. & Segal, D.M. Targeted antigen presentation using crosslinked antibody heteroaggregates. J. Immunol. 139, 1609–1616 ((1987).

3. Kawamura, H. & Berzofsky, J.A. Enhancement of antigenic potency in vitro and immunogenicity in vivo by coupling the antigen to anti-immunoglobulin. J. Immunol. 136, 58–65 (1986).

4. Casten, L.A. & Pierce, S.K. Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J. Immunol. 140, 404–410 ( 1988).

5. Lees, A., Morris, S.C., Thyphronitis, G., Holmes, J.M., Inman, J.K., & Finkelman, F.D. Rapid stimulation of large specific antibody responses with conjugates of antigen and anti-IgD antibody. J. Immunol. 145, 3594–3600 (1990).

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