Abstract
AbstractTo define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune activity and, in turn, can regulate the immune system to generate a physiologically synchronized response. Therefore, the brain has to represent information regarding the state of the immune system, which can occure in multiple ways. One such representation is an immunengram, a trace that is partially stored by neurons and partially by the local tissue. This review will discuss our current understanding of immunoception and immunengrams, focusing on their manifestation in a specific brain region, the insular cortex (IC).
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Reference84 articles.
1. Koren T, Rolls A. Immunoception: Defining brain-regulated immunity. Neuron. 2022;110:3425–8.
2. Berntson GG, Khalsa SS. Neural Circuits of Interoception. Trends Neurosci. 2021;44:17–28.
3. Chen WG, Schloesser D, Arensdorf AM, Simmons JM, Cui C, Valentino R, et al. The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self. Trends Neurosci. 2021;44:3–16.
4. Craig ADB. How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci. 2009;10:59–70.
5. Khalsa SS, Adolphs R, Cameron OG, Critchley HD, Davenport PW, Feinstein JS, et al. Interoception and Mental Health: A Roadmap. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3:501–13.
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