Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg.2017.15.pdf
Reference153 articles.
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4. Shalek, A. K. et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature 498, 236–240 (2013). A demonstration of how covariation in gene expression in scRNA-Seq data can be used to identify cellular circuits and molecular drivers of behaviour in seemingly identical immune cells. It also nicely demonstrates the use of microfluidic devices for targeted single-cell mRNA measurements (STA).
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