Spatial and temporal coordination of mitosis by Ran GTPase
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2410.pdf
Reference167 articles.
1. Drivas, G. T., Shih, A., Coutavas, E., Rush, M. G. & D'Eustachio, P. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. Mol. Cell. Biol. 10, 1793–1798 (1990).
2. Bischoff, F. R. & Ponstingl, H. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354, 80–82 (1991). Discovery that RCC1 is a guanine nucleotide-exchange factor for Ran GTPase.
3. Bischoff, F. R. & Ponstingl, H. Mitotic regulator protein RCC1 is complexed with a nuclear Ras-related polypeptide. Proc. Natl Acad. Sci. USA 88, 10830–10834 (1991).
4. Moore, M. S. & Blobel, G. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365, 661–663 (1993).
5. Melchior, F., Paschal, B., Evans, J. & Gerace, L. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123, 1649–1659 (1993). References 4 and 5 provided biochemical identification of Ran as a crucial nuclear transport factor.
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