Foxo1 integrates insulin signaling with mitochondrial function in the liver-Reference-Cited by-同舟云学术

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Foxo1 integrates insulin signaling with mitochondrial function in the liver

Published:2009-10-18 Issue:11 Volume:15 Page:1307-1311
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Cheng Zhiyong,Guo Shaodong,Copps Kyle,Dong Xiaochen,Kollipara Ramya,Rodgers Joseph T,Depinho Ronald A,Puigserver Pere,White Morris F

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2049.pdf

Reference34 articles.

1. Edgerton, D.S., Johnson, K.M. & Cherrington, A.D. Current strategies for the inhibition of hepatic glucose production in type 2 diabetes. Front. Biosci. 14, 1169–1181 (2009).

2. Postic, C. & Girard, J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J. Clin. Invest. 118, 829–838 (2008).

3. Lowell, B.B. & Shulman, G.I. Mitochondrial dysfunction and type 2 diabetes. Science 307, 384–387 (2005).

4. Kim, J.A., Wei, Y. & Sowers, J.R. Role of mitochondrial dysfunction in insulin resistance. Circ. Res. 102, 401–414 (2008).

5. Dong, X.C. et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 8, 65–76 (2008).

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