IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/ncomms13567.pdf
Reference62 articles.
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2. Hilkens, J. Recent translational research: oncogene discovery by insertional mutagenesis gets a new boost. Breast Cancer Res. 8, 102 (2006).
3. Klijn, C. et al. Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors. PLoS ONE 8, e62113 (2013).
4. Theodorou, V. et al. MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nat. Genet. 39, 759–769 (2007).
5. Chan, B. T. & Lee, A. V. Insulin receptor substrates (IRSs) and breast tumorigenesis. J. Mammary Gland Biol. Neoplasia 13, 415–422 (2008).
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