CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo-Reference-Cited by-同舟云学术

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CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo

Published:2014-01-12 Issue:6 Volume:29 Page:1437-1441
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Gregory G P,Hogg S J,Kats L M,Vidacs E,Baker A J,Gilan O,Lefebure M,Martin B P,Dawson M A,Johnstone R W,Shortt J

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu201510.pdf

Reference15 articles.

1. Savage KJ, Johnson NA, Ben-Neriah S, Connors JM, Sehn LH, Farinha P et al. MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood 2009; 114: 3533–3537.

2. Hu S, Xu-Monette ZY, Tzankov A, Green T, Wu L, Balasubramanyam A et al. MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. Blood 2013; 121: 4021–4031.

3. Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM . c-MYC recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene 2003; 22: 5707–5711.

4. Marshall NF, Peng J, Xie Z, Price DH . Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem 1996; 271: 27176–27183.

5. Gargano B, Amente S, Majello B, Lania L . P-TEFb is a crucial co-factor for Myc transactivation. Cell Cycle 2007; 6: 2031–2037.

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