The hypocretins: Setting the arousal threshold
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn808.pdf
Reference124 articles.
1. Gautvik, K. M. et al. Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proc. Natl Acad. Sci. USA 93, 8733–8738 (1996).The first detection of the mRNA that encodes preprohypocretin in a few thousand neurons in the lateral hypothalamus.
2. de Lecea, L. et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA 95, 322–327 (1998).The prediction of two carboxy-terminally amidated peptides, immunohistochemical mapping of the projections of the hypocretin neurons, detection of the peptides in dense-core vesicles at synapses and demonstration that the synthetic, amidated peptides have excitatory electrophysiological activity.
3. Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573–585 (1998).The independent discovery of the hypocretins and their two target receptors, detection of the endogenous peptides, determination of their exact structures and demonstration that the peptides stimulate short-term food intake.
4. Alvarez, C. E. & Sutcliffe, J. G. Hypocretin is an early member of the incretin gene family. Neurosci. Lett. (in the press).
5. Lee, J. H. et al. Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. Eur. J. Biochem. 266, 831–839 (1999).
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