Disrupted intrinsic functional brain topology in patients with major depressive disorder
-
Published:2021-08-12
Issue:
Volume:
Page:
-
ISSN:1359-4184
-
Container-title:Molecular Psychiatry
-
language:en
-
Short-container-title:Mol Psychiatry
Author:
Yang Hong, Chen Xiao, Chen Zuo-Bing, Li Le, Li Xue-Ying, Castellanos Francisco Xavier, Bai Tong-Jian, Bo Qi-Jing, Cao Jun, Chang Zhi-Kai, Chen Guan-Mao, Chen Ning-Xuan, Chen Wei, Cheng Chang, Cheng Yu-Qi, Cui Xi-Long, Duan Jia, Fang YiruORCID, Gong Qi-YongORCID, Guo Wen-Bin, Hou Zheng-Hua, Hu Lan, Kuang Li, Li Feng, Li Hui-Xian, Li Kai-Ming, Li Tao, Liu Yan-Song, Liu Zhe-Ning, Long Yi-ChengORCID, Lu Bin, Luo Qing-Hua, Meng Hua-Qing, Peng Daihui, Qiu Hai-Tang, Qiu Jiang, Shen Yue-Di, Shi Yu-Shu, Si Tian-Mei, Tang Yan-Qing, Wang Chuan-YueORCID, Wang Fei, Wang Kai, Wang Li, Wang XiangORCID, Wang YingORCID, Wang Yu-Wei, Wu Xiao-Ping, Wu Xin-Ran, Xie Chun-MingORCID, Xie Guang-Rong, Xie Hai-Yan, Xie PengORCID, Xu Xiu-Feng, Yang Jian, Yao Jia-Shu, Yao Shu-Qiao, Yin Ying-Ying, Yuan Yong-Gui, Zang Yu-Feng, Zhang Ai-Xia, Zhang Hong, Zhang Ke-Rang, Zhang Lei, Zhang Zhi-JunORCID, Zhao Jing-Ping, Zhou Rubai, Zhou Yi-Ting, Zhu Jun-Juan, Zhu Zhi-Chen, Zou Chao-Jie, Zuo Xi-NianORCID, Yan Chao-GanORCID
Abstract
AbstractAberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology
Reference62 articles.
1. Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10:11. 2. Sharp LK, Lipsky MS. Screening for depression across the lifespan: a review of measures for use in primary care settings. Am Fam Phys. 2002;66:1001–8. 3. Battle DE. Diagnostic and statistical manual of mental disorders (DSM). Codas. 2013;25:191–2. 4. Kaiser RH, Andrews-Hanna JR, Wager TD, Pizzagalli DA. Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA Psychiatry. 2015;72:603–11. 5. Mulders PC, van Eijndhoven PF, Schene AH, Beckmann CF, Tendolkar I. Resting-state functional connectivity in major depressive disorder: a review. Neurosci Biobehav Rev. 2015;56:330–44.
Cited by
76 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|