Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
-
Published:2024-04-26
Issue:
Volume:
Page:
-
ISSN:1359-4184
-
Container-title:Molecular Psychiatry
-
language:en
-
Short-container-title:Mol Psychiatry
Author:
Sharkey Rachel J., Bacon Chelsea, Peterson ZeruORCID, Rootes-Murdy Kelly, Salvador Raymond, Pomarol-Clotet Edith, Karuk Andriana, Homan PhilippORCID, Ji Ellen, Omlor Wolfgang, Homan StephanieORCID, Georgiadis Foivos, Kaiser Stefan, Kirschner MatthiasORCID, Ehrlich Stefan, Dannlowski UdoORCID, Grotegerd Dominik, Goltermann Janik, Meinert SusanneORCID, Kircher Tilo, Stein Frederike, Brosch KatharinaORCID, Krug AxelORCID, Nenadic IgorORCID, Sim Kang, Spalletta GianfrancoORCID, Banaj NerisaORCID, Sponheim Scott R.ORCID, Demro CarolineORCID, Ramsay Ian S.ORCID, King Margaret, Quidé YannORCID, Green Melissa JaneORCID, Nguyen Dana, Preda Adrian, Calhoun VinceORCID, Turner JessicaORCID, van Erp Theo, Nickl-Jockschat Thomas
Abstract
AbstractFormal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, the relationship between FTD symptom dimensions and patterns of regional brain volume loss in schizophrenia remains to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles by enrolling a large multi-site cohort acquired by the ENIGMA Schizophrenia Working Group (752 schizophrenia patients and 1256 controls), to unravel the neuroanatomy of FTD in schizophrenia and using virtual histology tools on implicated brain regions to investigate the cellular basis. Based on the findings of previous clinical and neuroimaging studies, we decided to separately explore positive, negative and total formal thought disorder. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but positive and negative FTD demonstrated a dissociation: negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD also showed associations with microglial cell types. These results provide an important step towards linking FTD to brain structural changes and their cellular underpinnings, providing an avenue for a better mechanistic understanding of this syndrome.
Publisher
Springer Science and Business Media LLC
Reference75 articles.
1. Andreasen NC. Thought, language, and communication disorders. II. Diagnostic significance. Arch Gen Psychiatry. 1979;36:1325–30. 2. DeLisi LE. Speech disorder in schizophrenia: review of the literature and exploration of its relation to the uniquely human capacity for language. Schizophr Bull. 2001;27:481–96. 3. Hartmann JA, Yuen HP, McGorry PD, Yung AR, Lin A, Wood SJ, et al. Declining transition rates to psychotic disorder in ‘ultra-high risk’ clients: Investigation of a dilution effect. Schizophr Res. 2016;170:130–6. 4. DeVylder JE, Muchomba FM, Gill KE, Ben-David S, Walder DJ, Malaspina D, et al. Symptom trajectories and psychosis onset in a clinical high-risk cohort: the relevance of subthreshold thought disorder. Schizophr Res. 2014;159:278–83. 5. Armando M, Pontillo M, De Crescenzo F, Mazzone L, Monducci E, Lo Cascio N, et al. Twelve-month psychosis-predictive value of the ultra-high risk criteria in children and adolescents. Schizophr Res. 2015;69:186–92.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|